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Novel strategies to optimize the photophysical properties of organic fluorophores are of great significance to the design of imaging probes to interrogate biology.While the 2-(2-hydroxyphenyl)-benzothiazole (HBT) fluorophore has attracted considerable attention in the field of fluorescence imaging, its short emission in the blue region and low quan

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Abstract Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch, whilst pain inhibition enhances itch.The neural mechanisms Fenugreek at the central nervous system (CNS) underlying these pain-itch interactions still need to be explored.Here, we revealed the contrasting role of orexin-producing neurons (ORX neuro

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